Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Atherosclerosis is comprehensive term for series of degenerative hyperplasic lesions such as thickening or sclerosis large- medium-sized arteries, causing decreased vascular-wall elasticity lumen diameter. Atherosclerotic cerebro-cardiovascular disease has become major concern human health recent years due to its clinical sequalae strokes heart attacks. Curcumin concoction treatment modulates several important signaling pathways related cellular migration, proliferation, cholesterol homeostasis, inflammation, gene transcription, among other relevant actions. Here, we provide an overview curcumin atherosclerosis prevention disclose the underlying mechanisms action effects.